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Mapping plant interactomes using literature curated and predicted protein-protein interaction data sets.

Authors
  • K, Lee
  • D, Thorneycroft
  • P, Achuthan
  • H, Hermjakob
  • Trey Ideker
Type
Published Article
Journal
The Plant Cell
Publisher
American Society of Plant Biologists
Volume
22
Issue
4
Pages
997–1005
Identifiers
DOI: 10.1105/tpc.109.072736
Source
Ideker Lab
License
Unknown

Abstract

Most cellular processes are enabled by cohorts of interacting proteins that form dynamic networks within the plant proteome. The study of these networks can provide insight into protein function and provide new avenues for research. This article informs the plant science community of the currently available sources of protein interaction data and discusses how they can be useful to researchers. Using our recently curated IntAct Arabidopsis thaliana protein-protein interaction data set as an example, we discuss potentials and limitations of the plant interactomes generated to date. In addition, we present our efforts to add value to the interaction data by using them to seed a proteome-wide map of predicted protein subcellular locations.

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