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Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques

Authors
  • Zhao, Fangzhu1, 2, 3
  • Joyce, Collin1, 2, 3
  • Burns, Alison1, 2, 3
  • Nogal, Bartek4
  • Cottrell, Christopher A.4
  • Ramos, Alejandra1, 2, 3, 5
  • Biddle, Trevor1, 2, 3
  • Pauthner, Matthias1, 2, 3
  • Nedellec, Rebecca1, 2, 3
  • Qureshi, Huma1, 2, 3, 5
  • Mason, Rosemarie6
  • Landais, Elise1, 2, 3, 5
  • Briney, Bryan1, 2, 7
  • Ward, Andrew B.2, 3, 4
  • Burton, Dennis R.1, 2, 3, 8
  • Sok, Devin1, 2, 3, 5
  • 1 Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
  • 2 Center for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA
  • 3 IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA
  • 4 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
  • 5 IAVI, New York, NY 10004, USA
  • 6 Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA
  • 7 Center for Viral Systems Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
  • 8 Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA 02114, USA
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Sep 08, 2020
Volume
32
Issue
10
Identifiers
DOI: 10.1016/j.celrep.2020.108122
PMID: 32905766
PMCID: PMC7487785
Source
PubMed Central
License
Unknown

Abstract

Zhao et al. report the isolation and characterization of neutralizing antibodies from BG505 SHIV-infected and BG505 SOSIP-immunized macaques. Antibody responses between immunization and natural infection are similar and protective epitope specificities mapped. A common neutralizing antibody lineage (public clonotype) is identified across several macaques targeting an immunodominant epitope.

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