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MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance.

Authors
  • 1
  • 1 Developmental Neurobiology and Regeneration Unit, Institut de Recerca Biomedica de Barcelona, Barcelona Science Park and Department of Cell Biology, University of Barcelona, Barcelona 08028, Spain.
Type
Published Article
Journal
Current Biology
0960-9822
Publisher
Elsevier
Publication Date
Volume
14
Issue
10
Pages
840–850
Identifiers
PMID: 15186740
Source
Medline
License
Unknown

Abstract

These data indicate that MAP1B phosphorylation is controlled by Netrin 1 and that the lack of MAP1B impairs Netrin 1-mediated chemoattraction in vitro and in vivo. Thus, MAP1B may be a downstream effector in the Netrin 1-signaling pathway.

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