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Many functions of the meiotic cohesin

Authors
  • Bardhan, Amit
Type
Published Article
Journal
Chromosome Research
Publisher
Springer-Verlag
Publication Date
Nov 18, 2010
Volume
18
Issue
8
Pages
909–924
Identifiers
DOI: 10.1007/s10577-010-9169-0
Source
Springer Nature
Keywords
License
Yellow

Abstract

Sister chromatids are held together from the time of their formation in S phase until they segregate in anaphase by the cohesin complex. In meiosis of most organisms, the mitotic Mcd1/Scc1/Rad21 subunit of the cohesin complex is largely replaced by its paralog named Rec8. This article reviews the specialized functions of Rec8 that are crucial for diverse aspects of chromosome dynamics in meiosis, and presents some speculations relating to meiotic chromosome organization.

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