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The many faces of Polycomb regulation by RNA.

Authors
  • Almeida, Mafalda1
  • Bowness, Joseph S1
  • Brockdorff, Neil2
  • 1 Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. , (United Kingdom)
  • 2 Developmental Epigenetics, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom. Electronic address: [email protected] , (United Kingdom)
Type
Published Article
Journal
Current opinion in genetics & development
Publication Date
Apr 01, 2020
Volume
61
Pages
53–61
Identifiers
DOI: 10.1016/j.gde.2020.02.023
PMID: 32403014
Source
Medline
Language
English
License
Unknown

Abstract

Many intricate pathways contribute to the timely control of gene expression during development. Polycomb repressive complexes (PRC1 and PRC2) and long non-coding RNAs (lncRNAs) are players associated with gene repression in various developmental processes such as X chromosome inactivation (XCI) and genomic imprinting. Historically, lncRNAs were proposed to directly recruit PRC2. However, recent evidence suggests that promiscuous interactions between PRC2 and RNA fine-tune the function of the complex through a multiplicity of mechanisms. A PRC2-recruitment model was definitively overturned in the paradigm of XCI by Xist RNA, being replaced by a novel mechanism which puts PRC1 in the spotlight. This review focuses on these recent advances in understanding the interplay between RNA and Polycomb complexes for gene expression control. Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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