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Mangostin enhances efficacy of aminolevulinic acid-photodynamic therapy against cancer through inhibition of ABCG2 activity.

Authors
  • Lai, Hung Wei1
  • Tani, Yukitaka2
  • Sukatta, Udomlak3
  • Rugthaworn, Prapassorn4
  • Thepyos, Asada5
  • Yamamoto, Shinkuro6
  • Fukuhara, Hideo7
  • Inoue, Keiji7
  • Yuasa, Hideya2
  • Nakamura, Hiroyuki8
  • Ogura, Shun-Ichiro9
  • 1 Center for Photodynamic Medicine, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505 Japan. , (Japan)
  • 2 School of Life Science and Technology, Tokyo Institute of Technology, 4259, Nagatsuta-cho, Midori-ku, Yokohama 226-8501 Japan. , (Japan)
  • 3 Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, 50 Ngamwongwan Rd, Lat Yao, Chatuchak, Bangkok 10900 Thailand. Electronic address: [email protected]. , (Thailand)
  • 4 Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, 50 Ngamwongwan Rd, Lat Yao, Chatuchak, Bangkok 10900 Thailand. , (Thailand)
  • 5 Quality Plus Biomedtech Co., Ltd. Headquarter: fl. 25, Jasmine International Tower, Chaeng Wattana road, Pak Kret district, Nonthaburi 11120 Thailand. , (Thailand)
  • 6 Department of Urology, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505 Japan. , (Japan)
  • 7 Center for Photodynamic Medicine, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505 Japan; Department of Urology, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505 Japan. , (Japan)
  • 8 Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259, Nagatsuta-cho, Midori-ku, Yokohama 226-8503 Japan. , (Japan)
  • 9 School of Life Science and Technology, Tokyo Institute of Technology, 4259, Nagatsuta-cho, Midori-ku, Yokohama 226-8501 Japan. Electronic address: [email protected]. , (Japan)
Type
Published Article
Journal
Photodiagnosis and Photodynamic Therapy
Publisher
Elsevier B.V.
Publication Date
Dec 01, 2023
Volume
44
Pages
103798–103798
Identifiers
DOI: 10.1016/j.pdpdt.2023.103798
PMID: 37696317
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Aminolevulinic acid-photodynamic therapy (ALA-PDT) is gaining attention as a potential method for treating select cancers due to its high specificity and low side effect feature. ALA enters cancer cells and accumulate as protoporphyrin IX (PpIX), which will then trigger phototoxicity following light irradiation. However, it is reported that some cancer cells have reduced efficacy of ALA-PDT due to high expression of ABCG2, a transporter involved in the PpIX efflux. In this study, we evaluated the effect of mangostin, a natural compound containing anti-tumor property, on the efficacy of ALA-PDT against cancer and the mechanism involved. We utilized TMK1 gastric cancer cell line, which has high ABCG2 expression, to evaluate the PpIX accumulation and phototoxicity exerted by ALA and mangostin co-addition. We found that co-addition of ALA and mangostin significantly increase the phototoxicity and PpIX accumulation in TMK1 cells. We also investigated the effect of mangostin on porphyrin-heme pathway enzymes and ABCG2 and found that the addition of mangostin reduce the activity of ABCG2, reducing PpIX efflux. These findings suggest that mangostin enhances the efficacy of ALA-PDT in cancer through inhibition of ABCG2 activity. Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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