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Manganese enhanced magnetic resonance imaging (MEMRI): A powerful new imaging method to study tinnitus

Authors
  • Cacace, Anthony T.
  • Brozoski, Tom
  • Berkowitz, Bruce
  • Bauer, Carol
  • Odintsov, Boris
  • Bergkvist, Magnus
  • Castracane, James
  • Zhang, Jinsheng
  • Holt, Avril Genene1, 2, 3, 4, 5, 6, 7, 6, 8, 9, 10, 11, 12, 6
  • 1 Department of Communication Sciences & Disorders
  • 2 Wayne State University Detroit
  • 3 Division of Otolaryngology
  • 4 Southern Illinois University School of Medicine
  • 5 Department of Anatomy and Cell Biology
  • 6 Wayne State University School of Medicine
  • 7 Department of Ophthalmology
  • 8 Biomedical Imaging Center
  • 9 Beckman Institute for Advanced Science and Technology
  • 10 University of Illinois at Champagne
  • 11 SUNY College of Nanoscale Science and Engineering
  • 12 Department of Otolaryngology
Type
Published Article
Journal
Hearing Research
Publisher
Elsevier BV
Publication Date
Jan 01, 2014
Accepted Date
Feb 10, 2014
Identifiers
DOI: 10.1016/j.heares.2014.02.003
Source
Elsevier
Keywords
License
Unknown

Abstract

•Manganese enhanced MRI (MEMRI) is a powerful new imaging modality to study tinnitus.•Voltage-gated calcium channels allow Mn2+entry which is retained by active neurons.•MEMRI allows for longitudinal probing of neuronal function independent of blood flow.•MEMRI is unaffected by scanner noise.•Customized nanoparticle constructs may have direct utility to tinnitus research.

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