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RNAi suppressor: The hidden weapon of SARS-CoV

Authors
  • Karjee, Sumona1
  • Mukherjee, Sunil Kumar2
  • 1 Prantae Solutions Private Limited, Bhubaneswar, 751 024, India , Bhubaneswar (India)
  • 2 Indian Agricultural Research Institute, New Delhi, 110 012, India , New Delhi (India)
Type
Published Article
Journal
Journal of Biosciences
Publisher
Springer-Verlag
Publication Date
Jul 16, 2020
Volume
45
Issue
1
Identifiers
DOI: 10.1007/s12038-020-00071-0
Source
Springer Nature
Keywords
License
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Abstract

The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question.

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