Management of Muscle-Invasive Bladder Cancer During a Pandemic: Impact of Treatment Delay on Survival Outcomes for Patients Treated With Definitive Concurrent Chemoradiotherapy

Benjamin W. Fischer-Valuck; Jeff M. Michalski; Joanna G. Harton; Alison Birtle; John P. Christodouleas; Jason A. Efstathiou; Vivek K. Arora; Eric H. Kim; Eric M. Knoche; Russell K. Pachynski; Joel Picus; Yuan James Rao; Melissa Reimers; Bruce J. Roth; Paul Sargos; Zachary L. Smith; Mohamed S. Zaghloul; Hiram A. Gay; Sagar A. Patel; Brian C. Baumann

doi:10.1016/j.clgc.2020.06.005

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Management of Muscle-Invasive Bladder Cancer During a Pandemic: Impact of Treatment Delay on Survival Outcomes for Patients Treated With Definitive Concurrent Chemoradiotherapy

Authors

Fischer-Valuck, Benjamin W.¹
Michalski, Jeff M.²
Harton, Joanna G.³
Birtle, Alison^{4, 5}
Christodouleas, John P.⁶
Efstathiou, Jason A.⁷
Arora, Vivek K.⁸
Kim, Eric H.⁹
Knoche, Eric M.⁸
Pachynski, Russell K.⁸
Picus, Joel⁸
Rao, Yuan James¹⁰
Reimers, Melissa⁸
Roth, Bruce J.⁸
Sargos, Paul^{11, 12}
Smith, Zachary L.⁹
Zaghloul, Mohamed S.^{13, 14}
Gay, Hiram A.²
Patel, Sagar A.¹
Baumann, Brian C.^{2, 6}

¹ Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
² Department of Radiation Oncology, Washington University School of Medicine in St Louis, St Louis, MO
³ Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁴ Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK
⁵ University of Manchester, Manchester, UK
⁶ Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
⁷ Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA
⁸ Division of Oncology, Washington University School of Medicine in St Louis, St Louis, MO
⁹ Division of Urology, Washington University School of Medicine in St Louis, St Louis, MO
¹⁰ Department of Radiation Oncology, George Washington University, Washington D.C.
¹¹ Department of Radiation Oncology, Jewish General Hospital, Montreal, QC, Canada
¹² Department of Radiotherapy, Institut Bergonié, Bordeaux, France
¹³ Radiation Oncology Department, Children’s Cancer Hospital, Cairo, Egypt
¹⁴ Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Type

Published Article

Journal

Clinical Genitourinary Cancer

Publisher

Elsevier

Publication Date

Jun 22, 2020

Volume

19

Issue

1

Pages

41–46

Identifiers

DOI: 10.1016/j.clgc.2020.06.005

PMID: 33187904

PMCID: PMC7306737

Source

PubMed Central

Keywords

Disciplines

Original Study

License

Unknown

Abstract

Limited data are available on the effect of treatment delays for initiating chemoradiotherapy (CRT) for muscle-invasive bladder cancer. We used the National Cancer Database and found that 1387 patients had started CRT < 90 days after transurethral resection of bladder tumor (TURBT) compared with 197 with delayed CRT (≥ 90 days after TURBT). On multivariable analysis, delayed CRT was not associated with differences in overall survival. These results suggest that short, strategic treatment delays during a pandemic can be considered based on clinician judgment.

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