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Management of elderly ulcerative colitis in Japan

Authors
  • Higashiyama, Masaaki1
  • Sugita, Akira2
  • Koganei, Kazutaka2
  • Wanatabe, Kenji3
  • Yokoyama, Yoko3
  • Uchino, Motoi3
  • Nagahori, Masakazu4
  • Naganuma, Makoto5
  • Bamba, Shigeki6
  • Kato, Shingo7
  • Takeuchi, Ken8
  • Omori, Teppei9
  • Takagi, Tomohisa10
  • Matsumoto, Satohiro11
  • Nagasaka, Mitsuo12
  • Sagami, Shintaro13
  • Kitamura, Kazuya14
  • Katsurada, Takehiko15
  • Sugimoto, Ken16
  • Takatsu, Noritaka17
  • And 6 more
  • 1 National Defense Medical College,
  • 2 Yokohama Municipal Citizen’s Hospital,
  • 3 Hyogo College of Medicine,
  • 4 Tokyo Medical and Dental University,
  • 5 Keio University School of Medicine,
  • 6 Shiga University of Medical Science,
  • 7 Saitama Medical University,
  • 8 Toho University Sakura Medical Centre,
  • 9 Tokyo Women’s Medical University,
  • 10 Kyoto Prefectural University of Medicine,
  • 11 Jichi Medical University,
  • 12 Fujita Health University School of Medicine,
  • 13 Kitasato University Kitasato Institute Hospital,
  • 14 Kanazawa University Hospital,
  • 15 Hokkaido University Graduate School of Medicine,
  • 16 Hamamatsu University School of Medicine,
  • 17 Fukuoka University Chikushi Hospital,
  • 18 The Jikei University School of Medicine,
  • 19 Tohoku University Graduate School of Medicine,
Type
Published Article
Journal
Journal of Gastroenterology
Publisher
Springer Japan
Publication Date
Apr 20, 2019
Volume
54
Issue
7
Pages
571–586
Identifiers
DOI: 10.1007/s00535-019-01580-y
PMID: 31025187
PMCID: PMC6685935
Source
PubMed Central
Keywords
License
Unknown

Abstract

Japan has the largest aging society, where many elderly people have intractable diseases including ulcerative colitis (UC). Along with the increasing total number of UC patients, the number of elderly UC patients has also been increasing and will continue to do so in the future. Although the clinical features and natural history of UC in the elderly have many similarities with UC in the non-elderly population, age-specific concerns including comorbidities, immunological dysfunction, and polypharmacy make the diagnosis and management of elderly UC challenging compared to UC in non-elderly patients. Based on increasing data related to elderly UC patients from Japan, as well as other countries, we reviewed the epidemiology, clinical course, differential diagnosis, management of comorbidities, surveillance, medical therapy, and surgery of UC in the elderly.

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