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Management of early aggressive rheumatoid arthritis during pregnancy and lactation.

Authors
  • Ostensen, Monika1
  • 1 Department of Rheumatology, and Clinical Immunology and Allergy, University Hospital, CH-3010 Bern, Switzerland. [email protected]
Type
Published Article
Journal
Expert Opinion on Pharmacotherapy
Publisher
Informa UK (Taylor & Francis)
Publication Date
June 2009
Volume
10
Issue
9
Pages
1469–1479
Identifiers
DOI: 10.1517/14656560902980194
PMID: 19505214
Source
Medline
License
Unknown

Abstract

This survey outlines the problems of drug therapy in women with early aggressive rheumatoid arthritis (RA) who desire children, are pregnant, or are lactating. Solutions for treatment that benefit the mother and do not harm the fetus or the breast-fed child are discussed. The most effective immunosuppressive drugs alone or in combination are contraindicated during pregnancy and, to a lesser degree, also during lactation. Judicious timing of therapy is therefore necessary, aiming at fast remission of symptoms with the most effective therapy and maintaining quiescent disease with drugs compatible with pregnancy or lactation.

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