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Mammary gland development from a single cell ‘omics view

Authors
  • Twigger, Alecia-Jane1, 2
  • Khaled, Walid T.1, 2
  • 1 Department of Pharmacology, University of Cambridge, Cambridge, UK
  • 2 Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK
Type
Published Article
Journal
Seminars in Cell and Developmental Biology
Publisher
Elsevier
Publication Date
Jun 01, 2021
Volume
114
Pages
171–185
Identifiers
DOI: 10.1016/j.semcdb.2021.03.013
PMID: 33810979
PMCID: PMC8158430
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

Understanding the complexity and heterogeneity of mammary cell subpopulations is vital to delineate the mechanisms behind breast cancer development, progression and prevention. Increasingly sophisticated tools for investigating these cell subtypes has led to the development of a greater understanding of these cell subtypes, complex interplay of certain subtypes and their developmental potential. Of note, increasing accessibility and affordability of single cell technologies has led to a plethora of studies being published containing data from mammary cell subtypes and their differentiation potential in both mice and human data sets. Here, we review the different types of single cell technologies and how they have been used to improve our understanding of mammary gland development.

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