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A mammalian in vitro model to study gangliogenesis from neural crest cells.

Authors
  • Boisseau, S
  • Poirier, V
  • Semonin, O
  • Leconte, L
  • Santha, M
  • Poujeol, C
  • Rougon, G
  • Simonneau, M
Type
Published Article
Journal
Journal de physiologie
Publication Date
Jan 01, 1991
Volume
85
Issue
3
Pages
117–122
Identifiers
PMID: 1818107
Source
Medline
License
Unknown

Abstract

In spite of considerable advances towards understanding lineages derived from neural crest cells using amphibian and avian embryos, the molecular mechanisms involved in the formation of mammalian peripheral ganglia remain largely unknown, mainly because of the lack of experimental systems that will allow their in vitro manipulation. Here, we present a novel mammalian in vitro model permitting to study gangliogenesis from neural crest cells. This model allowed us to manipulate molecules involved in cell-cell interactions. Our data are in favour of the existence of a hierarchy among adhesion molecules.

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