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Mammalian hibernation and regulation of lipid metabolism: a focus on non-coding RNAs.

Authors
Type
Published Article
Journal
Biochemistry (Moscow)
1608-3040
Publisher
Pleiades Publishing
Publication Date
Volume
79
Issue
11
Pages
1161–1171
Identifiers
DOI: 10.1134/S0006297914110030
PMID: 25540001
Source
Medline
License
Unknown

Abstract

Numerous species will confront severe environmental conditions by undergoing significant metabolic rate reduction. Mammalian hibernation is one such natural model of hypometabolism. Hibernators experience considerable physiological, metabolic, and molecular changes to survive the harsh challenges associated with winter. Whether as fuel source or as key signaling molecules, lipids are of primary importance for a successful bout of hibernation and their careful regulation throughout this process is essential. In recent years, a plethora of non-coding RNAs has emerged as potential regulators of targets implicated in lipid metabolism in diverse models. In this review, we introduce the general characteristics associated with mammalian hibernation, present the importance of lipid metabolism prior to and during hibernation, as well as discuss the potential relevance of non-coding RNAs such as miRNAs and lncRNAs during this process.

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