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Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1

Authors
  • Curnock, Rachel
  • Cullen, Peter J.
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Aug 25, 2020
Volume
133
Issue
16
Identifiers
DOI: 10.1242/jcs.249201
PMID: 32843536
PMCID: PMC7473646
Source
PubMed Central
Keywords
Disciplines
  • Research Article
License
Green

Abstract

Summary: CTR1 (SLC31A1) is the only known mammalian importer of copper. We show that CTR1 is a retromer complex cargo protein, and that retromer is required for cellular sensitivity to extracellular copper.

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