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Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?

Authors
  • Deuse, T
  • Schrepfer, S
  • Pelletier, M P
  • Fischbein, M P
  • Robbins, R C
  • Reichenspurner, H
Type
Published Article
Journal
Transplantation Proceedings
Publisher
Elsevier
Publication Date
Mar 01, 2007
Volume
39
Issue
2
Pages
569–572
Identifiers
PMID: 17362784
Source
Medline
License
Unknown

Abstract

When used in therapeutic doses, tacrolimus and sirolimus were more effective than FK778 to prolong cardiac allograft survival. However, with its antiproliferative effects on smooth muscle cells, its good tolerability, and its blockade of cytomegalovirus replication, FK778 proved effective to prevent chronic OAD development. Thus, FK778 may acquire an important role in maintenance therapy for the prevention of long-term fibroproliferative complications.

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