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[Malignant transformation of multiple chondroma. Apropos of a case].

Authors
  • Dujardin, F1
  • Salmeron, F
  • Cambon-Michot, C
  • Thomine, J M
  • 1 Clinique Chirurgicale Orthopédique et Traumatologique, CHU de Rouen.
Type
Published Article
Journal
Revue de chirurgie orthopedique et reparatrice de l'appareil moteur
Publication Date
1997
Volume
83
Issue
2
Pages
160–163
Identifiers
PMID: 9231184
Source
Medline
License
Unknown

Abstract

Malignant transformation of multiple chondromas observed in Ollier's disease is a well known possibility. In the clinical case of a 52 year old woman reported here, the sarcomatous transformation of two endochondromatous foci occurred successively in less than one year. One was located in the calcaneus, the other within the proximal metaphysis of the ipsilateral fibula. This case is worth reporting for two reasons: the successive occurrence of these sarcomatous lesions led to a amputation below the knee, later completed by an extended radical resection of the fibula. This combination allowed to preserve the knee with a good functional result and without local recurrence, this clinical case may be compared with that reported by Goodman in 1984. Both cases show that sarcomatous transformations may occur almost simultaneously after a long quiscent period and suggest the existence of a factor that could trigger or favor a malignant transformation process.

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