Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Malignant transformation of bronchogenic cyst revealed by 99mTc-MIBI-SPECT.

Authors
  • Fiorelli, Alfonso
  • Rambaldi, Pierfrancesco
  • Accardo, Marina
  • Santini, Mario
Type
Published Article
Journal
Asian Cardiovascular and Thoracic Annals
Publisher
SAGE Publications
Publication Date
Jun 01, 2012
Volume
20
Issue
3
Pages
347–349
Identifiers
DOI: 10.1177/0218492311436258
PMID: 22718731
Source
Medline
License
Unknown

Abstract

Adenocarcinoma arising from a mediastinal cyst was detected by exercise technetium-99m hexakis-2-methoxyisobuty-lisonitrile (99m)Tc-MIBI scintigraphy in a 65-year-old woman with known coronary disease. This guided further investigations and resection of the tumor which stained positive for P-glycoprotein. Three years earlier, myocardial scintigraphy was negative, probably due to down-expression of P-glycoprotein because the cells were in the early stages of carcinogenesis. After completing malignant transformation, the high P-glycoprotein expression resulted in MIBI uptake on the second myocardial scintigraphy.

Report this publication

Statistics

Seen <100 times