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Malignant hyperthermia resolving with discontinuation of sevoflurane alone.

Authors
  • Abolkhair, Abdullah
  • Seefelder, Christian
Type
Published Article
Journal
Saudi journal of anaesthesia
Publication Date
Apr 01, 2011
Volume
5
Issue
2
Pages
229–232
Identifiers
DOI: 10.4103/1658-354X.82816
PMID: 21804810
Source
Medline
Keywords
License
Unknown

Abstract

An otherwise healthy 13 year old developed hypercarbia and increased temperature during anesthesia with sevoflurane. Discontinuation of sevoflurane, surface cooling, and hyperventilation resulted in prompt resolution. However, hyperkalemia continued to raise the suspicion for malignant hyperthermia, which was ultimately confirmed by ryanodine receptor gene sequencing. The case underlines the importance of intraoperative monitoring of end-tidal CO2 and temperature and the potential benefits of early discontinuation of inhalational anesthetics in the presence of signs and symptoms suspicious for malignant hyperthermia. The severe hyperkalemia suggests that standard guidelines for diagnosis and treatment of malignant hyperthermia, including dantrolene treatment, should be followed whenever malignant hyperthermia is suspected.

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