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Malignant B cell immunoblastic lymphoma expressing CD30 antigen in the terminal phase of a multiple myeloma.

Authors
Type
Published Article
Journal
Applied pathology
Publication Date
Volume
7
Issue
6
Pages
375–381
Identifiers
PMID: 2561814
Source
Medline

Abstract

An acute terminal phase of a Bence Jones kappa plasma cell myeloma developed 22 months after chemotherapy is presented. The patient's symptoms were fever, cytopenias, adenomegalies and hepatomegaly. A lymph node biopsy showed an immunoblastic polymorphic kappa B cell lymphoma, expressing CD30 antigen. After new polychemotherapy the patient died because of bleeding and infection. Autopsy revealed a decrease in the tumour with defective immunophenotype. The few reported cases have been reviewed with emphasis on clinical aspects, prognosis and morphology, The significance of CD30 positivity (activation marker) in a high-grade lymphoma is discussed.

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