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Male papillomavirus infection and genotyping in the Qingyuan area

Authors
  • Yin, Wei-Guo1
  • Yang, Meng1
  • Peng, Lei1
  • Liu, Yan-Mei1
  • Cheng, Bin1
  • Xuan, Shu-Xia1
  • Chen, Chen1
  • Tan, Feng-Jun2
  • 1 The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, No. B24, Xincheng Yinquan Road, Qingcheng District, Qingyuan, Guangdong, 511518, China , Qingcheng District, Qingyuan (China)
  • 2 Qingyuan People’s Hospital, Guangdong, Qingyuan, 511518, China , Guangdong (China)
Type
Published Article
Journal
Virology Journal
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 16, 2020
Volume
17
Issue
1
Identifiers
DOI: 10.1186/s12985-020-01423-w
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundThis study aims to screen the male human papillomavirus (HPV) infection status and genotyping in Qingcheng District, Qingyuan City, Guangdong Province, China to provide a reference basis for formulating prevention strategies for HPV infection.MethodsThe present study collected urethral epithelium or scraped penile epidermis from high-risk male patients in Qingyuan People's Hospital during the last five years, extracted DNA fragments using the boiling method, and detected 23 types of HPV genotypes by PCR-reverse blot hybridization.ResultsThe positive detection rate was 54.31% of 1044 males with high risk of HPV (567/1044). Among these males, the positive detection rate of HPV was the highest in patients initially diagnosed with warts, and the rate was 66.47%. Five main HPV types are identified as follows: HPV6 18.87% (197/1044), HPV11 10.25% (107/1044), HPV52 8.81% (92/1044), HPV16 6.90% (72/1044), and HPV51 5.08% (53/1044). Among these HPV-infected patients, single infection mainly by low-risk HPV6 and HPV11 accounted for 56.61% (321/567); high- and low-risk combined HPV co-infections accounted for 29.10% (165/567). The HPV infected patients was mainly between 21 and 40 years old, and the HPV infection rate was higher with increased age.ConclusionsThe HPV infection rate in the Qingyuan area is higher than in other areas and the main infection is single infection. Furthermore, HPV52, HPV16, and HPV51 are the main high-risk infection types, while HPV6 and HPV11 are the main low-risk infection types.

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