Affordable Access

Access to the full text

Male gender and kidney illness are associated with an increased risk of severe laboratory-confirmed coronavirus disease

  • Murillo-Zamora, Efrén1
  • Trujillo, Xóchitl2
  • Huerta, Miguel2
  • Ríos-Silva, Mónica3
  • Mendoza-Cano, Oliver4
  • 1 Unidad de Medicina Familiar, No. 19, Instituto Mexicano del Seguro Social, Av. Javier Mina 301, Col. Centro, Colima, Colima, C.P.28000, México , Colima (Mexico)
  • 2 Universidad de Colima, Av. 25 de julio 965, Col. Villas San Sebastián, Colima, C.P. 28045, México , Colima (Mexico)
  • 3 Centro Universitario de Investigaciones Biomédicas, Av. 25 de julio 965, Col. Villas San Sebastián, Colima, C.P. 28045, México , Colima (Mexico)
  • 4 Universidad de Colima, km. 9 carretera Colima-Coquimatlán, Col. Jardines del Llano, C.P. 28400, Coquimatlán, Colima, México , Colima (Mexico)
Published Article
BMC Infectious Diseases
Springer (Biomed Central Ltd.)
Publication Date
Sep 16, 2020
DOI: 10.1186/s12879-020-05408-6
Springer Nature


BackgroundTo identify factors predicting severe coronavirus disease 2019 (COVID-19) in adolescent and adult patients with laboratory-positive (quantitative reverse-transcription polymerase chain reaction) infection.MethodA retrospective cohort study took place, and data from 740 subjects, from all 32 states of Mexico, were analyzed. The association between the studied factors and severe (dyspnea requiring hospital admission) COVID-19 was evaluated through risk ratios (RRs) and 95% confidence intervals (CIs).ResultsSevere illness was documented in 28% of participants. In multiple analysis, male gender (RR = 1.13, 95% CI 1.06–1.20), advanced age ([reference: 15–29 years old] 30–44, RR = 1.02, 95% CI 0.94–1.11; 45–59, RR = 1.26, 95% CI 1.15–1.38; 60 years or older, RR = 1.44, 95% CI 1.29–1.60), chronic kidney disease (RR = 1.31, 95% CI 1.04–1.64) and thoracic pain (RR = 1.16, 95% CI 1.10–1.24) were associated with an increased risk of severe disease.ConclusionsTo the best of our knowledge, this is the first study evaluating predictors of COVID-19 severity in a large subset of the Latin-American population. Male gender and kidney illness were independently associated with the risk of severe COVID-19. These results may be useful for health care protocols for the early detection and management of patients that may benefit from opportune and specialized supportive medical treatment.

Report this publication


Seen <100 times