Affordable Access

deepdyve-link
Publisher Website

Male exposure to bisphenol A (BPA) and semen quality in the Home Observation of Periconceptional Exposures (HOPE) cohort.

Authors
  • Pollard, Sarah Hatch1
  • Cox, Kyley J2
  • Blackburn, Brenna E2
  • Wilkins, Diana G3
  • Carrell, Douglas T4
  • Stanford, Joseph B2
  • Porucznik, Christina A5
  • 1 Division of Otolaryngology, Department of Surgery, University of Utah, Salt Lake City, UT, USA; Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA.
  • 2 Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA.
  • 3 Division of Medical Laboratory Science, Department of Pathology, University of Utah, Salt Lake City, UT, USA.
  • 4 Division of Andrology, Department of Surgery, University of Utah, Salt Lake City, UT, USA.
  • 5 Division of Public Health, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA. Electronic address: [email protected]
Type
Published Article
Journal
Reproductive toxicology (Elmsford, N.Y.)
Publication Date
Dec 01, 2019
Volume
90
Pages
82–87
Identifiers
DOI: 10.1016/j.reprotox.2019.08.014
PMID: 31445078
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Exposure to bis-phenol A (BPA) has been associated with reduced semen quality. The objective of this study was to examine associations between BPA measured in serial daily first-morning urine samples and semen quality parameters among men trying to conceive. This prospective, preconception cohort included 161 men ages 18-40 without known subfertility. Men collected daily, first morning urine during their female partner's fertile window. Semen samples were collected through intercourse after the fertile window. Samples from 161 men were analyzed. Higher geometric mean (GM) BPA exposures (ng/mL) were found among men with abnormal sperm tail morphology (GM = 3.12, 95% CI = 2.43, 4.01) compared to men with normal morphologic findings (GM = 2.39, 95% CI = 2.17, 2.74). There was no association with sperm count. Higher exposure to BPA was associated with abnormal sperm tail morphology in this prospective, pre-conception cohort. Copyright © 2019 Elsevier Inc. All rights reserved.

Report this publication

Statistics

Seen <100 times