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Malaria transmission-blocking drugs: implications and future perspectives.

Authors
  • Wadi, Ishan1
  • Singh, Pargat1
  • Nath, Mahendra1
  • Anvikar, Anupkumar R2
  • Sinha, Abhinav2
  • 1 Department of Chemistry, University of Delhi, Delhi, 110007, India. , (India)
  • 2 ICMR-National Institute of Malaria Research, Dwarka, New Delhi, 110077, India. , (India)
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Jun 01, 2020
Volume
12
Issue
11
Pages
1071–1101
Identifiers
DOI: 10.4155/fmc-2020-0026
PMID: 32378423
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

As the world gets closer to eliminating malaria, the scientific community worldwide has begun to realize the importance of malaria transmission-blocking interventions. The onus of breaking the life cycle of the human malaria parasite Plasmodium falciparum predominantly rests upon transmission-blocking drugs because of emerging resistance to commonly used schizonticides and insecticides. This third part of our review series on malaria transmission-blocking entails transmission-blocking potential of preclinical transmission-blocking antimalarials and other non-malaria drugs/experimental compounds that are not in clinical or preclinical development for malaria but possess transmission-blocking potential. Collective analysis of the structure and the activity of these experimental compounds might pave the way toward generation of novel prototypes of next-generation transmission-blocking drugs.

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