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Malaria: toxins, cytokines and disease.

Authors
  • Jakobsen, P H
  • Bate, C A
  • Taverne, J
  • Playfair, J H
Type
Published Article
Journal
Parasite immunology
Publication Date
May 01, 1995
Volume
17
Issue
5
Pages
223–231
Identifiers
PMID: 7675508
Source
Medline
License
Unknown

Abstract

In this review the old concept of severe malaria as a toxic disease is re-examined in the light of recent discoveries in the field of cytokines. Animal studies suggest that the induction of TNF by parasite-derived molecules may be partly responsible for cerebral malaria and anemia, while hypoglycaemia may be due to direct effects of similar molecules on glucose metabolism. These molecules appear to be phospholipids and we suggest that when fully characterized they might form the basis of antitoxic therapy for malaria.

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