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Making ends meet: coordination between RNA 3'-end processing and transcription initiation.

Authors
  • Andersen, Pia K
  • Jensen, Torben Heick
  • Lykke-Andersen, Søren
Type
Published Article
Journal
Wiley Interdisciplinary Reviews - RNA
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2013
Volume
4
Issue
3
Pages
233–246
Identifiers
DOI: 10.1002/wrna.1156
PMID: 23450686
Source
Medline
License
Unknown

Abstract

RNA polymerase II (RNAPII)-mediated gene transcription initiates at promoters and ends at terminators. Transcription termination is intimately connected to 3'-end processing of the produced RNA and already when loaded at the promoter, RNAPII starts to become configured for this downstream event. Conversely, RNAPII is 'reset' as part of the 3'-end processing/termination event, thus preparing the enzyme for its next round of transcription--possibly on the same gene. There is both direct and circumstantial evidence for preferential recycling of RNAPII from the gene terminator back to its own promoter, which supposedly increases the efficiency of the transcription process under conditions where RNAPII levels are rate limiting. Here, we review differences and commonalities between initiation and 3'-end processing/termination processes on various types of RNAPII transcribed genes. In doing so, we discuss the requirements for efficient 3'-end processing/termination and how these may relate to proper recycling of RNAPII.

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