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Make killers sweeter: targeting metabolic checkpoints of NK cells

Authors
  • Wei, Haiming1, 1
  • Fu, Binqing1, 1
  • 1 University of Science and Technology of China, Hefei, Anhui, China , Hefei (China)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 03, 2020
Volume
21
Issue
9
Pages
970–971
Identifiers
DOI: 10.1038/s41590-020-0738-x
Source
Springer Nature
License
Yellow

Abstract

Group 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism.

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