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Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases

Authors
  • Gupta, Sonia Vidushi
  • Schmidt, Kristina Hildegard1
  • 1 Cancer Biology and Evolution Program, H. Lee Moffitt Cancer Center and Research, Institute, Tampa, FL 33612, USA
Type
Published Article
Journal
Genes
Publisher
MDPI AG
Publication Date
Feb 18, 2020
Volume
11
Issue
2
Identifiers
DOI: 10.3390/genes11020205
PMID: 32085395
PMCID: PMC7074392
Source
PubMed Central
Keywords
License
Green

Abstract

With roles in DNA repair, recombination, replication and transcription, members of the RecQ DNA helicase family maintain genome integrity from bacteria to mammals. Mutations in human RecQ helicases BLM, WRN and RecQL4 cause incurable disorders characterized by genome instability, increased cancer predisposition and premature adult-onset aging. Yeast cells lacking the RecQ helicase Sgs1 share many of the cellular defects of human cells lacking BLM, including hypersensitivity to DNA damaging agents and replication stress, shortened lifespan, genome instability and mitotic hyper-recombination, making them invaluable model systems for elucidating eukaryotic RecQ helicase function. Yeast and human RecQ helicases have common DNA substrates and domain structures and share similar physical interaction partners. Here, we review the major cellular functions of the yeast RecQ helicases Sgs1 of Saccharomyces cerevisiae and Rqh1 of Schizosaccharomyces pombe and provide an outlook on some of the outstanding questions in the field.

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