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Magnetic property, DFT calculation, and biological activity of bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] complex.

Authors
  • Mroueh, Mohammad
  • Daher, Costantine
  • Hariri, Essa
  • Demirdjian, Sally
  • Isber, Samih
  • Choi, Eun Sang
  • Mirtamizdoust, Babak
  • Hammud, Hassan H
Type
Published Article
Journal
Chemico-Biological Interactions
Publisher
Elsevier
Publication Date
Apr 25, 2015
Volume
231
Pages
53–60
Identifiers
DOI: 10.1016/j.cbi.2015.02.023
PMID: 25753321
Source
Medline
Keywords
License
Unknown

Abstract

The dinuclear complex bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.

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