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Magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride for the efficient enrichment of glucocorticoids in cosmetics.

Authors
  • Li, Yanxia1
  • Chen, Xiaoman1
  • Xia, Ling1
  • Xiao, Xiaohua2
  • Li, Gongke3
  • 1 School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China. , (China)
  • 2 School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China. Electronic address: [email protected] , (China)
  • 3 School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Journal of chromatography. A
Publication Date
Nov 22, 2019
Volume
1606
Pages
460382–460382
Identifiers
DOI: 10.1016/j.chroma.2019.460382
PMID: 31353072
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In this work, magnetic metal-organic frameworks-101 functionalized with graphite-like carbon nitride material (Fe3O4/g-C3N4/MIL-101) has been simply prepared for the efficient enrichment of glucocorticoids in cosmetics. Due to the introduction of g-C3N4, the water stability of MIL-101 has been greatly improved. This composite material also showed better selectivity for glucocorticoids than those for polycyclic aromatic hydrocarbons and benzene compounds due to the hydrogen bonding effect with g-C3N4 and the size-matching effect with MIL-101. When the prepared material was used as the sorbents in magnetic solid-phase extraction (MSPE) and coupled with ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS), a sensitive MSPE-UPLC-MS/MS method was developed. Under the optimal conditions, the calibration curves were linear over the concentration ranging from 0.01 to 2 μg/L with correlation coefficients (R2) between 0.9915 and 0.9995. The limit of detection (LOD) was as low as 2 ng/L with the RSDs lower than 5.5%. The recoveries ranged from 77.3% to 113%. The LOD of glucocorticoids in real samples analysis was improved by nearly three orders of magnitude compared to current literature records. The results indicated that Fe3O4/g-C3N4/MIL-101 could be used as MSPE extractant to determine glucocorticoids in complex cosmetics matrix. Copyright © 2019 Elsevier B.V. All rights reserved.

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