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Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain

Authors
  • Adamiano, Alessio1
  • Wu, Victoria M2
  • Carella, Francesca1
  • Lamura, Gianrico3
  • Canepa, Fabio3, 4
  • Tampieri, Anna1
  • Iafisco, Michele1
  • Uskoković, Vuk2, 5
  • 1 Institute of Science & Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, Italy
  • 2 Department of Biomedical & Pharmaceutical Sciences, Center for Targeted Drug Delivery, Chapman University, Irvine, CA 92618-1908, USA
  • 3 Institute of Superconductors, Oxides & Other Innovative Materials & Devices (SPIN), National Research Council (CNR), Corso Perrone 24, 16152 Genova, Italy
  • 4 Department of Chemistry & Industrial Chemistry, University of Genova, Via Dodecaneso 31, 16146 Genova, Italy
  • 5 Department of Bioengineering, University of Illinois, Chicago, IL 60607-7052, USA
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
May 24, 2019
Volume
14
Issue
10
Pages
1267–1289
Identifiers
DOI: 10.2217/nnm-2018-0372
PMID: 31124760
PMCID: PMC6615412
Source
PubMed Central
Keywords
License
Unknown

Abstract

Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate ([email protected]), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for [email protected] and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.

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