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MAG Gene Variation and Cortical Gray Matter Volume in First Episode Schizophrenia

Authors
  • Voineskos, Aristotle N.1
  • Lang, Donna J.2
  • Zai, Gwyneth1
  • Bulgin, Natalie1
  • Shaikh, Sajid1
  • Su, Wayne2
  • Kopala, Lili C.2
  • MacEwan, G. William2
  • Thornton, Allen E.3
  • Smith, Geoffrey N.2
  • Austin, Jehannine C.2
  • Honer, William G.2
  • Kennedy, James L.1
  • 1 University of Toronto, Section of Neurogenetics, Centre for Addiction and Mental Health, R-31 CAMH, 250 College Street, Toronto, ON, M5T1R8, Canada , Toronto (Canada)
  • 2 University of British Columbia, Centre for Complex Disorders, Vancouver, British Columbia, V5Z 1L8, Canada , Vancouver (Canada)
  • 3 Simon Fraser University, Department of Psychology, Burnaby, British Columbia, V5A 1S6, Canada , Burnaby (Canada)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Mar 18, 2008
Volume
2
Issue
2
Pages
117–122
Identifiers
DOI: 10.1007/s11682-008-9023-6
Source
Springer Nature
Keywords
License
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Abstract

Evidence implicating myelin related genes in the pathophysiology of schizophrenia is accumulating. Abnormalities of brain structure at the onset of psychosis may be related to variation in genes such as myelin associated glycoprotein (MAG). Subjects with first episode schizophrenia (n = 30) or schizoaffective disorder (n = 11), and healthy comparison subjects (n = 43) participated in an MRI scan. Two single nucleotide polymorphisms (rs720309, rs720308) in the MAG gene were genotyped. MAG genotype variation predicted cortical gray matter volume in first episode schizophrenia patients (p = 0.039), but not in controls (p = 0.827). Cortical gray matter, total gray matter, total white matter, and ventricular cerebrospinal fluid volumes did not differ between groups. Genetic variation in the MAG gene may predict cortical gray matter volume differences in patients in the first episode of schizophrenia or schizoaffective disorder.

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