Affordable Access

Access to the full text

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis

Authors
  • Muliaditan, Tamara1
  • Caron, Jonathan1
  • Okesola, Mary1
  • Opzoomer, James W.1
  • Kosti, Paris1
  • Georgouli, Mirella2
  • Gordon, Peter1
  • Lall, Sharanpreet1
  • Kuzeva, Desislava M.1
  • Pedro, Luisa3
  • Shields, Jacqueline D.3
  • Gillett, Cheryl E.1
  • Diebold, Sandra S.4
  • Sanz-Moreno, Victoria2
  • Ng, Tony1
  • Hoste, Esther5, 6
  • Arnold, James N.1
  • 1 Guy’s Campus, School of Cancer and Pharmaceutical Sciences, King’s College London, Faculty of Life Sciences and Medicine, London, SE1 1UL, UK , London (United Kingdom)
  • 2 Guy′s Campus, Tumour Plasticity Laboratory, Randall Centre for Cell and Molecular Biophysics, King′s College London, London, SE1 1UL, UK , London (United Kingdom)
  • 3 Hutchison/Medical Research Council Research Centre, Medical Research Council Cancer Cell Unit, Cambridge, CB2 0XZ, UK , Cambridge (United Kingdom)
  • 4 National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, UK , Hertfordshire (United Kingdom)
  • 5 VIB Center for Inflammation Research, Unit for Cellular and Molecular Pathophysiology, Ghent-Zwijnaarde, B-9052, Belgium , Ghent-Zwijnaarde (Belgium)
  • 6 Ghent University, Department of Biomedical Molecular Biology, Ghent, B-9052, Belgium , Ghent (Belgium)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
Jul 27, 2018
Volume
9
Issue
1
Identifiers
DOI: 10.1038/s41467-018-05346-7
Source
Springer Nature
License
Green

Abstract

The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread.

Report this publication

Statistics

Seen <100 times