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Macrophages in cancer and infectious diseases: the 'good' and the 'bad'.

Authors
  • Porta, Chiara
  • Riboldi, Elena
  • Totaro, Maria Grazia
  • Strauss, Laura
  • Sica, Antonio
  • Mantovani, Alberto
Type
Published Article
Journal
Immunotherapy
Publisher
Future Medicine
Publication Date
Oct 01, 2011
Volume
3
Issue
10
Pages
1185–1202
Identifiers
DOI: 10.2217/imt.11.116
PMID: 21995571
Source
Medline
License
Unknown

Abstract

Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.

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