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A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists.

Authors
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Volume
56
Issue
3
Pages
1010–1020
Identifiers
PMID: 17328080
Source
Medline
License
Unknown

Abstract

Increased expression of Siglec-1 in circulating SSc monocytes and tissue macrophages suggests that type I IFN-mediated activation of monocytes occurs in SSc, possibly through TLR activation of IFN secretion. These observations indicate a potential role for type I IFN-activated monocyte/macrophages in the pathogenesis of SSc.

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