Affordable Access

deepdyve-link
Publisher Website

Macamides: A review of structures, isolation, therapeutics and prospects.

Authors
  • Zhu, Hongkang1
  • Hu, Bin2
  • Hua, Hanyi1
  • Liu, Chang1
  • Cheng, Yuliang1
  • Guo, Yahui1
  • Yao, Weirong1
  • Qian, He3
  • 1 School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. , (China)
  • 2 School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected] , (China)
  • 3 School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Food research international (Ottawa, Ont.)
Publication Date
Dec 01, 2020
Volume
138
Issue
Pt B
Pages
109819–109819
Identifiers
DOI: 10.1016/j.foodres.2020.109819
PMID: 33288191
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Macamides, the major bioactive compounds of Lepidium meyenii (Walp.) or Maca, are a unique class of non-polar, long chain fatty acid N-benzylamides with fertility-enhancing, neuroprotective, neuro-modulatory, anti-fatigue and anti-osteoporosis effects. However, the relationship between the structures and pharmacological effects of macamides have not been established so far. In addition, little is known regarding their biosynthetic pathways and the mechanisms underlying the biological activities. In this review, we have summarized the methods currently used for the extraction, purification and synthesis of macamides. Their pharmacological effects, clinical prospects and biomedical applications have also been discussed. Current data strongly suggest that macamides are a promising bio-active agent, and further studies are warranted to elucidate their mechanisms of action. Copyright © 2020 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times