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A lytic viral long noncoding RNA modulates the function of a latent protein.

Authors
Type
Published Article
Journal
Journal of Virology
Publisher
American Society for Microbiology
Volume
88
Issue
3
Pages
1843–1843
Identifiers
DOI: 10.1128/JVI.03251-13
Source
Izumiya Lab dermatology-ucdavis
License
Unknown

Abstract

Latent Kaposi s sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.

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