Affordable Access

deepdyve-link
Publisher Website

Lysosome: regulator of lipid degradation pathways.

Authors
  • Settembre, Carmine1
  • Ballabio, Andrea2
  • 1 Dulbecco Telethon Institute, Via Pietro Castellino 111, 80131, Naples, Italy; Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131, Naples, Italy; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Medical Genetics, Department of Translational and Medical Science, Federico II University, Via Pansini 5, 80131 Naples, Italy. Electronic address: [email protected] , (Italy)
  • 2 Telethon Institute of Genetics and Medicine (TIGEM), Via Pietro Castellino 111, 80131, Naples, Italy; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Medical Genetics, Department of Translational and Medical Science, Federico II University, Via Pansini 5, 80131 Naples, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Trends in cell biology
Publication Date
December 2014
Volume
24
Issue
12
Pages
743–750
Identifiers
DOI: 10.1016/j.tcb.2014.06.006
PMID: 25061009
Source
Medline
Keywords
License
Unknown

Abstract

Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting and primarily relies on the activity of the endolysosomal system, to which the autophagosome targets substrates for degradation. Recent studies have revealed that the lysosomal-autophagic pathway plays an important part in the early steps of lipid degradation. In this review, we discuss the transcriptional mechanisms underlying co-regulation between lysosome, autophagy, and other steps of lipid catabolism, including the activity of nutrient-sensitive transcription factors (TFs) and of members of the nuclear receptor family. In addition, we discuss how the lysosome acts as a metabolic sensor and orchestrates the transcriptional response to fasting.

Report this publication

Statistics

Seen <100 times