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Lysosomal agents inhibit store-operated Ca 2+ entry

Authors
  • Morgan, Anthony J.
  • Galione, Antony
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Jan 27, 2021
Volume
134
Issue
2
Identifiers
DOI: 10.1242/jcs.248658
PMID: 33328326
PMCID: PMC7860125
Source
PubMed Central
Keywords
License
Green

Abstract

Summary: Lysosomal agents uncouple ER Ca2+-release from store-operated Ca2+ entry, predominantly by inhibiting Stim1 oligomerization and its activation of Orai.

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