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Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis.

Authors
  • Deng, Wenlin
  • Balazs, Louisa
  • Wang, De-An
  • Van Middlesworth, Lester
  • Tigyi, Gabor
  • Johnson, Leonard R
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Jul 01, 2002
Volume
123
Issue
1
Pages
206–216
Identifiers
PMID: 12105849
Source
Medline
License
Unknown

Abstract

(1) LPA prevents and rescues IEC-6 from apoptosis elicited by 4 different mechanisms. (2) This antiapoptotic activity is mediated through LPA1 and LPA2 receptors through the inhibition of caspase-3/CPP32 activation. (3) LPA protects enterocytes against radiation-induced apoptosis. This study suggests that in patients undergoing cancer therapy, dietary LPA might have therapeutically useful antiapoptotic capacity in the intestinal epithelium.

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