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Lysogeny in Streptococcus pneumoniae

Authors
  • Garriss, Geneviève1
  • Henriques-Normark, Birgitta1, 2, 3
  • 1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
  • 2 Clinical Microbiology, Karolinska University Hospital, Bioclinicum, 171 76 Stockholm, Sweden
  • 3 Lee Kong Chian School of Medicine (LKC) and Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore 639798, Singapore
Type
Published Article
Journal
Microorganisms
Publisher
MDPI AG
Publication Date
Oct 07, 2020
Volume
8
Issue
10
Identifiers
DOI: 10.3390/microorganisms8101546
PMID: 33036379
PMCID: PMC7600539
Source
PubMed Central
Keywords
License
Green

Abstract

Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates of the human pathogen Streptococcus pneumoniae are frequently lysogenic, and genomic studies have allowed the classification of these phages into distinct phylogenetic groups. Here, we review the recent advances in the characterization of temperate pneumococcal phages, with a focus on their genetic features and chromosomal integration loci. We also discuss the contribution of phages, and specific phage-encoded features, to colonization and virulence. Finally, we discuss interesting research perspectives in this field.

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