Affordable Access

Lysis enhancement: a novel form of interaction between beta-lactam antibiotics.

Authors
Type
Published Article
Journal
Journal of medical microbiology
Publication Date
Volume
8
Issue
1
Pages
205–208
Identifiers
PMID: 1092867
Source
Medline

Abstract

A novel form of synergy has been observed to occur between cephalexin and certain other beta-lactam antibiotics. In the presence of cephalexin a reduction was found in the concentration of other beta-lactam agents needed to induce lysis of Escherichia coli; the effect was particularly marded when cephalexin was allowed to act for a short time before the addition of the second agent. The basis of this type of synergy--which is not likely to be of therapeutic value--is discussed in terms of a theroy perviously put forward, whcih suggests that penicillins and cephalosporins have two distinct sites of action in Gram-negative bacilli.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments