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Lymphocyte transformation studies in drug hypersensitivity

Authors
  • R.J. Warrington
  • K.S. Tse
Publication Date
May 05, 1979
Source
PMC
Keywords
Disciplines
  • Medicine
License
Unknown

Abstract

In a group of patients with clinically diagnosed drug hypersensitivity the in vitro lymphocyte response to the suspected drug was assessed by the lymphocyte transformation test. The test gave positive results in all 15 patients with penicillin-induced immediate or accelerated allergic reactions and positive immediate skin-test reactivity to the major or the minor antigenic determinant of penicillin, or both, but in only 3 of the 12 patients with delayed-onset maculopapular rashes induced by penicillin, despite positive immediate reactivity to the skin-test reagents.

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