Affordable Access

Lymphocyte mitogenesis induced by a mammalian liver protein that specifically binds desialylated glycoproteins.

Authors
  • A Novogrodsky
  • G Ashwell
Publication Date
Feb 01, 1977
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

A purified rabbit liver membrane protein that binds desialylated glycoproteins has been shown to be a mitogen for human peripheral lymphocytes. The mitogenic activity is specific for desialylated thymus-derived (T)-cells. The loss of mitogenicity upon exposure of the binding protein to neuraminidase and the inhibitory potency of asialo-orosomucoid support the conclusion that the site involved in the binding of asialoglycoproteins is also responsible for the mitogenic effect on desialylated lymphocytes. The potential relevance of this phenomenon to the etiology of hepatocellular necrosis is considered.

Report this publication

Statistics

Seen <100 times