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Lymphocyte Count at 4 Days Postoperatively: A Reliable Screening Marker for Surgical Site Infection After Posterior Lumbar Decompression Surgery.

Authors
  • Iwata, Eiichiro1
  • Shigematsu, Hideki1
  • Yamamoto, Yusuke1
  • Tanaka, Masato1
  • Okuda, Akinori2
  • Morimoto, Yasuhiko1
  • Masuda, Keisuke1
  • Nakajima, Hiroshi3
  • Koizumi, Munehisa4
  • Tanaka, Yasuhito1
  • 1 Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan. , (Japan)
  • 2 Department of Emergency and Critical Care Medicine, Nara Medical University, Nara, Japan. , (Japan)
  • 3 Department of Orthopaedic Surgery, Otemae Hospital, Osaka, Japan. , (Japan)
  • 4 Department of Spine Surgery, Nara Prefecture General Medical Center, Nara, Japan. , (Japan)
Type
Published Article
Journal
Spine
Publication Date
Sep 15, 2018
Volume
43
Issue
18
Identifiers
DOI: 10.1097/BRS.0000000000002617
PMID: 29481380
Source
Medline
Language
English
License
Unknown

Abstract

Case-control study. To identify laboratory markers for surgical site infection (SSI) in posterior lumbar decompression surgery, which are not affected by operative factors, and to determine the diagnostic cutoffs of these markers. Numerous laboratory markers are used for the early detection of SSI; however, these markers may be affected by operative factors. The study included 182 participants. They were divided into an SSI group (patients who developed deep SSI; n = 8) and a no-SSI group (n = 174). We reviewed data on the C-reactive protein level and total white blood cell count and differential count before posterior lumbar decompression surgery and 1 and 4 days postoperatively. We determined which markers differed significantly between the groups and identified the markers that were not affected by operative factors (operative time, intraoperative blood loss, and number of operative segments) in the no-SSI group. We then determined the diagnostic cutoffs of these unaffected markers using receiver operating characteristic curves. We identified the lymphocyte percentage at 4 days postoperatively (cutoff, <19.4%; sensitivity, 80.0%; specificity, 62.5%; area under the curve, 0.78) and lymphocyte count at 4 days postoperatively (cutoff, <1010/μL; sensitivity, 93.7%; specificity, 62.5%; area under the curve, 0.78) as reliable markers. Lymphocyte percentage and count at 4 days postoperatively are reliable markers for SSI after posterior lumbar decompression surgery. Lymphocyte count at 4 days postoperatively can be considered as a superior marker for screening because it has a high sensitivity and can be measured early. 4.

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