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Lymphocyte 5'-nucleotidase activities in normal dogs and in dogs with malignant lymphoma.

Authors
  • Sarmiento, U M
  • Valli, V E
Type
Published Article
Journal
Veterinary Immunology and Immunopathology
Publisher
Elsevier
Publication Date
Dec 01, 1986
Volume
13
Issue
4
Pages
281–288
Identifiers
PMID: 3029941
Source
Medline
License
Unknown

Abstract

Plasma membrane 5'-nucleotidase (5'NT) activity was assayed in lymph node lymphocytes from seven normal control dogs and in malignant lymphocytes from 25 dogs with lymphoma. The lymphoid tumors were classified according to the NCI Working Formulation into five histologic subtypes. When compared with normal controls significantly lower 5'NT activities were found in the lymphoblastic, small lymphocytic and diffuse large (noncleaved) subtypes while no significant differences were observed in the immunoblastic or small noncleaved groups. In addition, dogs with hypercalcemia or paraproteinemia had decreased 5'NT levels. However, no significant differences were found between prognostic groups or histologic subtypes of the NCI classification. In conclusion, canine lymphoma subtypes had generally decreased 5'NT activities which appeared to reflect the B or T cell lineage, degree of maturation and enzyme activity of the cell of origin.

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