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Lupus-erythematosus-Like Eruption Induced by Trichophyton mentagrophytes Infection

Authors
  • Boralevi, F.
  • Léauté-Labrèze, C.
  • Roul, S.
  • Couprie, B.
  • Taïeb, A.
Type
Published Article
Journal
Dermatology
Publisher
S. Karger AG
Publication Date
Jun 13, 2003
Volume
206
Issue
4
Pages
303–306
Identifiers
DOI: 10.1159/000069941
PMID: 12771470
Source
Karger
Keywords
License
Green
External links

Abstract

Background: Several factors are known to trigger acute manifestations of lupus erythematosus (drugs, ultraviolet radiation, bacterial or viral infections, pregnancy), but fungal infections have never been reported to induce lupus-like lesions. We describe 2 children with tinea capitis caused by Trichophyton mentagrophytes (TM), who developed transient skin and serological manifestations of systemic lupus erythematosus. Patients: Case 1, a 3-year-old girl, had a kerion due to TM transmitted by an octodon, and a facial skin eruption suggestive of systemic lupus erythematosus. Antinuclear antibodies (ANA) were positive at 1:250. After griseofulvin treatment, the lupus-like rash completely regressed, and the ANA titre decreased. Case 2, a 4-year-old girl, had occipital kerion and an annular scaly erythema on the shoulder caused by TM. She also had a non-scaly rash on the face and a recent history of photosensitivity. The ANA titre was positive at 1:8,000. Cutaneous lesions disappeared after an 8-week griseofulvin therapy, and ANA titres decreased progressively. Conclusions: ‘New pets’ are usually the vectors of TM, especially familiar rodents like the degu of Chile (also named octodon). In our 2 cases, lupus-like rashes began before the onset of griseofulvin treatment, suggesting a pathogenic role of the dermatophyte. A wide variety of lesions named ‘mycides’ was described several decades ago associated with TM infections. We hypothesize that these mycides and the TM-induced lupus-like lesions reported in our 2 cases could represent the same entity.

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