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Lupus autoantigens: Their origins, forms, and presentation

Authors
  • Doyle, Hester A.1
  • Yan, Jun1
  • Liang, Bailin1
  • Mamula, Mark J.1
  • 1 Yale University School of Medicine, New Haven, CT, 16520-8031 , New Haven
Type
Published Article
Journal
Immunologic Research
Publisher
Humana Press
Publication Date
Oct 01, 2001
Volume
24
Issue
2
Pages
131–147
Identifiers
DOI: 10.1385/IR:24:2:131
Source
Springer Nature
Keywords
License
Yellow

Abstract

The immune system has developed a number of mechanisms by which to distin guish self from foreign proteins. These mechanisms are found throughout the ontogeny of B and T cell development and include the deletion of autoreactive cells in central lymphoid organs and the induction of self-tolerance in the periphery. However, any failure of these mechanisms for self-tolerance may result in autoimmune disease. Efforts in our laboratory have been directed at under-standing how autoimmunity is initiated and maintained in both the B and T cell compartment, with particular interest in the autoimmunity of systemic lupus erythematosus (SLE). This review will focuson our studies on the forms of self-antigens that may be involved in the original “antigenic sin” of SLE and in the role of B lymphocytes as autoantigen presenting cells. We will also discuss whether costimulation is a formal requirement for the induction and maintenance of autoimmunity. Finally, we have provided a model for how all of these individual elements may contribute to the autoimmune processes leading to pathology.

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