Affordable Access

deepdyve-link
Publisher Website

Lung function and bronchial responsiveness after Mycoplasma pneumoniae infection in early childhood.

Authors
  • Kjaer, Birgitte B
  • Jensen, Jørgen S
  • Nielsen, Kim G
  • Fomsgaard, Anders
  • Böttiger, Blenda
  • Dohn, Birthe
  • Bisgaard, Hans
Type
Published Article
Journal
Pediatric pulmonology
Publication Date
Jun 01, 2008
Volume
43
Issue
6
Pages
567–575
Identifiers
DOI: 10.1002/ppul.20813
PMID: 18435477
Source
Medline
License
Unknown

Abstract

Mycoplasma (M.) pneumoniae has been associated with exacerbation of symptoms in asthmatic school children and adults; and an etiological role in asthma has been suggested. The purpose of this study was to investigate whether infection with M. pneumoniae in early childhood has a long-term influence on lung function and bronchial responsiveness. In a retrospective, clinical cohort-study children younger than 5 years-of-age when PCR-tested for M. pneumoniae were enrolled. Sixty-five children with clinical symptoms suggesting infection with M. pneumoniae during an epidemic season completed a clinical follow-up examination including lung function testing (28 PCR-positive and 37 PCR-negative). In addition to the PCR-test for M. pneumoniae all respiratory tract specimens were additionally tested for other atypical bacteria and for viruses by PCR. Lung function was measured as specific airway resistance by whole-body plethysmography and bronchial hyperresponsiveness was assessed by cold, dry air hyperventilation. Neither baseline lung function nor bronchial response to cold dry air hyperventilation differed between M. pneumoniae-positive and -negative children: mean baseline lung function were 1.17 versus 1.21 (kPa sec), P = 0.45; and mean change in specific resistance was 13% versus 9%, P = 0.42. In conclusion, M. pneumoniae infection in early childhood was not associated with long-term effects on lung function and bronchial hyperresponsiveness 2 years after infection.

Report this publication

Statistics

Seen <100 times