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[Lung disease after long-term inhalation of organic dusts in employees of a drug firm (author's transl)].

Authors
  • Wiessmann, K J
  • Vosberg, A
Type
Published Article
Journal
Deutsche medizinische Wochenschrift (1946)
Publication Date
Apr 03, 1981
Volume
106
Issue
14
Pages
431–436
Identifiers
PMID: 6908557
Source
Medline
License
Unknown

Abstract

Nine patients, as employees of a drug firm exposed to pancreatin and other organic substances in dust form for long periods of time, complained of non-specific breathing disorders and exercise dyspnoea. Investigation revealed predominantly restrictive-obstructive disorders of ventilation with diffuse emphysema and evidence of abnormal oxygen diffusion. In two patients the chest X-ray revealed signs of acute alveolitis, in a third a marked pulmonary fibrosis after exposure for several years. Six of seven patients reacted positively to a prick test with pancreatin. Precipitating antibodies were demonstrated in only one patient. Immunopathological and chemical-toxic effects of pancreatin dust may be causes of the described pulmonary disease.

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